brain pills
Dopamine
- positive feelings associated with reward or reinforcement
- reduced levels can lead to depression in some
Norepinephrine
- affects fight or flight response along with adrenaline
- depression may occur with too little
- mania may result from an excess
- changes in levels do not affect mood in every person
Desvenlafaxine: +1X
Serotonin
- a number of functions from gut to blood clotting to sexual function
- SSRIs specifically work on serotonin
Desvenlafaxine: +10X
- SNRIs target both serotonin and norepinephrine
- Tricyclic antidepressants (TCAs) also affect norepinephrine and serotonin, but they have the added effect of influencing histamine and acetylcholine
- SSRIs do not affect histamine and acetylcholine and are safer for cardiovascular reasons
Mine
| Compound | SERT | NET | DAT | 5-HT1A | 5-HT2A | 5-HT2B | 5-HT2C | 5-HT3 | 5-HT6 | 5-HT7 | α1 | α2 | D2 | H1 | mACh |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trazodone | 160–367 | ≥8,500 | ≥7,400 | 96–118 | 20–45 | 74–189 | 224–402 | >10,000 | >10,000 | 1,782 | 12–153 | 106–728 | ≥3,500 | 220–1,100 | >10,000 |